The National Heart, Lung, and Blood Institute-funded Production Assistance for Cellular Therapies (PACT) program: Eighteen years of cell therapy.

Clin Transl Sci · 2021 · PMC8604220 · PMID 34286927

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11 Following a phase I dose‐escalation safety study, a 60‐subject, multisite phase IIa clinical trial showed that PACT‐produced MSCs were well‐tolerated and showed a trend for improvement in oxygenation index in the treated group. 12 A phase IIb trial jointly supported by the Department of Defense and PACT 3/NHLBI is underway at the time of writing this manuscript.

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