Central synaptopathy is the most conserved feature of motor circuit pathology across spinal muscular atrophy mouse models.

In contrast to the strong denervation found in SMNΔ7 and Smn 2B/ - mice, the QL muscle of Taiwanese mutants exhibited only a modest and variable degree of denervated NMJs at end-stage that did not reach statistical significance on either genetic background ( Figures 6 A and 6B; Figures S2 E and S2F).

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