Multiplex CRISPR/Cas9 genome editing in hematopoietic stem cells for fetal hemoglobin reinduction generates chromosomal translocations.

Mol Ther Methods Clin Dev · 2021 · PMC8605315 · PMID 34853798

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did not reach statistical significanceno p-value reported

Consistent with the trend observed on flow cytometric assessment, where HbF/HbA ratio was compared in single-edited arms by HPLC, HbF reinduction appeared to be more effective with targeting of the HBG-113 rather than the BCL11A-ee, but the difference did not reach statistical significance ( Figures 2 G and 2H).

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highly significantno p-value reported

p values of <0.05 are taken to be significant (∗) and p values of <0.001 are taken to be highly significant (∗∗).

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a nonsignificant trendno p-value reported

We found a nonsignificant trend toward higher HbF levels where HBG-113 was targeted for single editing in comparison with BCL11A-ee.

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