Association of single nucleotide polymorphisms with insulin secretion, insulin sensitivity, and diabetes in women with a history of gestational diabetes mellitus.

The risk C-allele in the rs2943641 polymorphism, near the insulin receptor substrate 1 gene ( IRS1 ), showed a trend towards association with increased HOMA-IR (beta = 0.36, SE 0.18, p = 0.050), and the T-allele of the rs4607103 polymorphism, near the ADAM metallopeptidase with thrombospondin type 1 motif 9 gene ( ADAMTS9 ), was associated with postpartum diabetes (OR = 2.12, SE 0.22, p = 0.00055).

also in 53,322 other papers