In the embryonic cell line HEK293T, svn-dEX3 and svn-2B showed a trend toward preferential PM translocation compared to svn-wt, despite equivalent expression levels ( Fig. 1 B).
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Wild type, dEX3 and 2B survivin isoforms localize to the tumor cell plasma membrane, are secreted in exosomes, and interact with extracellular tubulin.
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