Bone turnover and mineral metabolism in adult patients with hypophosphatasia treated with asfotase alfa.

Compared with baseline NTx levels (11.8 nM BCE/L [10.0, 17.2]), there was a numerical increase in NTx levels at 3 months (13.2 nM BCE/L [9.9, 17.0]; P = 0.435) and 6 months (13.3 nM BCE/L [11.1, 16.0]; P = 0.528) that did not reach statistical significance.

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In parallel, actual resorptive activity determined by NTx exhibited a nonsignificant trend to be transiently increased and eventually decreased, suggesting a progressively stable situation during the course of treatment without further need for enhanced remodeling.

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