Loss of mutual protection between human osteoclasts and chondrocytes in damaged joints initiates osteoclast-mediated cartilage degradation by MMPs.

Sci Rep · 2021 · PMC8608887 · PMID 34811438

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showed a trendno p-value reported

Osteoclasts cultured on cartilage secreted active MMP8 and MMP9 and siRNA-mediated inhibition of either MMP showed a trend towards reduced GAG release from cartilage by osteoclasts.

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