The evolutionary conserved TLDc domain defines a new class of (H⁺)V-ATPase interacting proteins.

In contrast, the constructs with both the poly-E motif and the TLDc domain, Ncoa7 (751–943), Ncoa7 (593–943) and Tldc2 (2–212), showed a trend toward stronger interactions with the V-ATPase in comparison with the TLDc domain-only constructs, Ncoa7 (775–943) and Tldc2 (44–212) (Fig. 5 B,C).

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