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Efficacy of Istradefylline, an Adenosine A2A Receptor Antagonist, as Adjunctive Therapy to Levodopa in Parkinson's Disease: A Pooled Analysis of 8 Phase 2b/3 Trials.

J Parkinsons Dis · 2021 · PMC8609697 · PMID 34486986

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showed a trendno p-value reported
Motor function (UPDRS Part III ON) also showed a trend toward improvement.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.