Evaluation of 30 DNA damage response and 6 mismatch repair gene mutations as biomarkers for immunotherapy outcomes across multiple solid tumor types.

Cancer Biol Med · 2021 · PMC8610155 · PMID 33960179

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did not reach statistical significanceno p-value reported

In addition, patients with DDR gene mutations in ATR , BLM , BRIP1 , CHEK2 , ERCC2 , ERCC3 , ERCC5 , FANCA , FANCC , PARP1 , POLD1 , RAD51 , RAD51B , and RAD51C had significantly longer median survival than other patients, although this difference did not reach statistical significance because of the small number of mutant patients.

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