Anti-SARS-CoV-2 antibodies elicited by COVID-19 mRNA vaccine exhibit a unique glycosylation pattern.

The trends of the rest of the IgG3 glycan modifications, as well as of all glycan alterations in anti-RBD IgG2, which appeared only post-boost, were similar to what we observed in IgG1, but they did not reach statistical significance in our cohort.

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To determine whether this response was unique to the newly formed IgGs or to an overall trend in elderly individuals, we compared the FcγR-binding capacity of total IgGs ( Figure S3 C) and found no baseline differences between the populations.

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