Nanovibrational stimulation inhibits osteoclastogenesis and enhances osteogenesis in co-cultures.

However, these changes did not reach statistical significance; an increase in cathepsin K at day 1 in the nanovibrational group was the only significant difference observed.

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Looking at 2D qPCR transcriptional data for the CD14 + cultures, genes involved is osteoclast formation—TRAP and OSCAR (osteoclast-associated receptor) 26 had a slight trend towards increased up-regulation with nanovibrational stimulation at day 2 and 3 (Fig. 2 g).

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