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Comparison of the effects of open vs. closed skill exercise on the acute and chronic BDNF, IGF-1 and IL-6 response in older healthy adults.

BMC Neurosci · 2021 · PMC8614060 · PMID 34823469

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To the contrary, we observed in both groups a decrease of basal IGF-1 levels at the end of the 12-week intervention (with statistically significant changes in the cOSE group and a tendency towards significance in the cCSE group).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.