A clear trend in the potencies of the treatments emerged (average EC 50 of at least three independent experiments): admix (0.54 pM), HPH SNA (10.5 pM), HHH SNA (53.8 pM), HHM SNA (185 pM), MHM SNA (684 pM), and BMPS SNA (4820 pM) ( Figure 2 A).
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Chemically Tuning the Antigen Release Kinetics from Spherical Nucleic Acids Maximizes Immune Stimulation.
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