Hemoglobin glycation index, calculated from a single fasting glucose value, as a prediction tool for severe hypoglycemia and major adverse cardiovascular events in DEVOTE.

Baseline HGI showed a trend toward association with baseline microvascular disease markers and a significant association with prospective cardiovascular risk; moreover, these results support the initial findings of ADVANCE that HGI is not a better predictor of cardiovascular outcomes than HbA 1c in a patient population with advanced diabetes at high risk for cardiovascular events.

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