Sex-Specific Metabolic Pathways Were Associated with Alzheimer's Disease (AD) Endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery Cohort.

In parallel, one metabolite, kynurenate, was associated with AD in males after Bonferroni correction ( p < 8.17 × 10 −4 ) (β = −1.04, 95% CI = −1.58 to −0.54, p = 7.63 × 10 −5 ) ( Table 2 ) and 100 of 230 metabolites showed nominally significant associations in males ( Supplementary Table S1 ).

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