The nature of the plasmid backbone itself is clearly significant, as shown by Andrews et al., where the same mAb gene expressed from the pVAX plasmid, traditionally used for DNA vaccines, yielded lower mAb titers than when expressed from a gWiz plasmid [ 69 ].
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In Vivo Electroporation of Plasmid DNA: A Promising Strategy for Rapid, Inexpensive, and Flexible Delivery of Anti-Viral Monoclonal Antibodies.
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