Safety and Efficacy of Combined Low-Dose Lithium and Low-Dose Aspirin: A Pharmacological and Behavioral Proof-of-Concept Study in Rats.

Pharmaceutics · 2021 · PMC8619680 · PMID 34834241

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did not reach statistical significanceno p-value reported

Compatible with the general knowledge that most patients who take aspirin develop acute mucosal lesions while Li treatment is not associated with digestive tract maladies, chronic administration of aspirin indeed led to a significant decrease in gastric mucosal PGE2 levels as compared to control ( Figure 7 ), whereas the decrease induced by Li-only treatment did not reach statistical significance.

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