Blend Segregation in Tablets Manufacturing and Its Effect on Drug Content Uniformity-A Review.

Pharmaceutics · 2021 · PMC8620778 · PMID 34834324

Europe PMC DOI

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a decreasing trendno p-value reported

As a result, the coarse particles slid to the front, whereas fines accumulated near the inclined wall and emptied first into rotating dies, which translated to an excess of fines in the first tablets and a decreasing trend with process time.

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did not reach statistical significanceno p-value reported

Generally, dry granulated batches were characterized by lower content RSD; however, the difference did not reach statistical significance.

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