Genetic Polymorphisms Affecting Ranibizumab Response in High Myopia Patients.

Pharmaceutics · 2021 · PMC8620862 · PMID 34834388

Europe PMC DOI

hedged sentences

0.0630

closest p · 1.3× alpha

0.1000

boldest claim

The sentences

almost significantp = 0.063so close (0.05 < p ≤ 0.1)

Furthermore, VEGFA (rs3025000) showed almost significant differences about their genotype distribution among control and study groups ( p = 0.063).

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showed a trendp = 0.073so close (0.05 < p ≤ 0.1)

At 6-months follow-up ( Table 4 B), we found that ARMS2 (rs10490924) G allele is associated with increased BCVA improvement (OR = 1.95; 95%CI = 0.98–3.83; p = 0.037) and showed a trend for the association with worsening ( p = 0.073) compared to the T allele.

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close to significancep < 0.1so close (0.05 < p ≤ 0.1)

As we can see, F13A1 (rs5985), ARMS2 (rs10490924), CFH (rs1061170) and VEGFA (rs3025040) are the only SNPs not showing significant ( p > 0.05) or close to significance ( p < 0.1) differences about their genotype distribution among control and study groups, or deviations from the H-W. 3.2.

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