BiP Heterozigosity Aggravates Pathological Deterioration in Experimental Amyotrophic Lateral Sclerosis.

However, in this case, the immunoreactivity detected in mSOD1/BiP +/− mice showed a numerical trend towards to be higher than in mSOD1 mice having normal expression of BiP (different probability levels compared to control genotypes; Figure 3 A,B).

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We first analyzed the weight gain in the four genotypes which proved a trend towards a decrease in double mutants compared to the other three genotypes when animals were 11 week-old, reflected in the 2-way ANOVA (with repeated measures) statistics for the variable age (F(2,70) = 6.57, p < 0.01) and in its 2-way interaction with the variable genotype (F(6,70) = 2.93, p < 0.05), although the effect did not reach statistical significance with the post hoc analysis ( Figure 1 A).

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