<i>CD46</i> Genetic Variability and HIV-1 Infection Susceptibility.

Furthermore, rs2796265 genotypes correlate with a highly significant CD46 mRNA splicing quantitative locus in several tissues: fibroblast ( p = 1.4 × 10 −259 ), oesophagus ( p = 1.7 × 10 −188 ), immortalized B-lymphocytes ( p = 2.1 × 10 −57 ), or brain-cortex ( p = 1.3 × 10 −25 ) ( Figure 4 ). 4.

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Nine SNPs located in the CD46 locus were genotyped previously [ 40 ], and none of them, except rs2796265, showed a nominally significant association with HIV-1 status ( p = 10 −3 ) ( Supplementary Table S1 ).

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