Integrated immunovirological profiling validates plasma SARS-CoV-2 RNA as an early predictor of COVID-19 mortality.

To compare predictive accuracies at DSO60, we selected three additional analytes highly significant ( P ≤ 0.001) in univariate Cox ( Fig. 2G ): CytoScore, CXCL13, and RAGE ( Fig. 4B ).

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Defective early ADCC responses were also significantly associated with fatality, whereas we found only a nonsignificant trend for neutralization capacity.

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In the validation cohort, the predictive accuracy of the model combining vRNA, Angiopoietin-2, age, and sex did not reach statistical significance (at DSO60: AUC = 0.86; 95% CI: 0.29 to 1.00) ( Fig. 4D ).

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