The tumor immune microenvironment of primary and metastatic HER2- positive breast cancers utilizing gene expression and spatial proteomic profiling.

Several lymphocyte-related signatures trended toward having higher expression in primary tumors including TIGIT, CTLA4, T cells, CD8 T cells, PD1, cytotoxic cells, lymphoid cells, TH1, natural killer cells, cytotoxicity, TIS, exhausted CD8, PD-L2, and B7-H3, but did not reach statistical significance with an adjusted p-value (Fig. 1 B, Additional file 1 : Table S2).

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