A prospective observational study for justification, safety, and efficacy of a third dose of mRNA vaccine in patients receiving maintenance hemodialysis.

Comparing the titer of IgG directed against the RBD of the spike glycoprotein of the SARS-CoV-2 (anti-RBD IgG) measured with chemoluminescence assay and the neutralizing capacity of the serum, we observed a highly significant ( P < 0.0001) and strong ( r 2 = 0.67) positive correlation ( Figure 3 g).

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However, when the profile of tolerance was compared between patients on MHD according to the intensity of the humoral response after 2Ds of vaccine, a significant trend for more side effects was observed in patients with high response ( Figure 4 c and d).

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