OncomiRs miR-106a and miR-17 negatively regulate the nucleoside-derived drug transporter hCNT1.

Cell Mol Life Sci · 2021 · PMC8629896 · PMID 34647142

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showed a trendno p-value reported

Changes of hCNT1 mRNA expression showed a trend toward an increase after silencing miR-106a in both CRC and PDAC cell lines, whereas this trend was only observed in PDAC cell lines following miR-17 silencing (Fig. 4 C).

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an increasing trendno p-value reported

Under conditions of miR-106a and miR-17 knockdown using both approaches, nucleoside uptake rates in spheroids showed an increasing trend, although this difference fell short of statistical significance (Fig. 6 B).

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