Large Multicohort Study Reveals a Prostate Cancer Susceptibility Allele at 5p15 Regulating <i>TERT via</i> Androgen Signaling-Orchestrated Chromatin Binding of E2F1 and MYC.

TERT expressions showed an elevated trend in metastasis prostate tumors in several independent cohorts of PCa even though the significance was not strong in Taylor and Yu datasets ( Figure 2H and Supplementary Figures S2J–L ).

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We also observed a clear trend in the CPGEA Nature 2020 dataset showing C allele associating with poor prognosis ( Supplementary Figure S7A ).

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