KCNQ and KCNE Isoform-Dependent Pharmacology Rationalizes Native American Dual Use of Specific Plants as Both Analgesics and Gastrointestinal Therapeutics.

Here, we found that tannic acid constitutively opened KCNQ1 at –80 mV and inhibited it at more positive potentials ( Figures 9B–D ), leading to modest tannic acid-induced hyperpolarization of E M in oocytes expressing KCNQ1, although this did not reach statistical significance ( Figure 9E ).

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