Platelet Phenotype Analysis of COVID-19 Patients Reveals Progressive Changes in the Activation of Integrin αIIbβ3, F13A1, the SARS-CoV-2 Target EIF4A1 and Annexin A5.

Front Cardiovasc Med · 2021 · PMC8632253 · PMID 34859078

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showed a trendno p-value reported

Both thiol isomerases showed a trend toward higher levels in the non-surviving COVID-19 patients, although the results were not significant ( Figures 6A,B ).

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highly significantno p-value reported

Unexpectedly, the proteome analysis showed the strongest change with a highly significant reduction in the total amount of ITGA2B in platelets from COVID-19 patients compared to healthy controls and—similar to αIIbβ3 activation data—an even stronger decrease in non-surviving patients compared to surviving COVID-19 patients.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.