Indeed, transfer of female offspring ceacal content into young microbiota-depleted female mice for 5 weeks was associated with increased weight of some adipose tissues in GMT Veh-CE-treated mice as opposed to CE-Veh-treated mice, as well as a strong trend to increase glucose-stimulated insulin secretion, which was observed only 4 weeks post-GMT.
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The postnatal window is critical for the development of sex-specific metabolic and gut microbiota outcomes in offspring.
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The sentences
The weight of the BAT ( P = .051) and visceral adipose tissues ( P = .056) were borderline significant in CE-CE and Veh-CE female offspring ( Figure 4c ).