Consistent with the effect of CCR1 KO in OPM2 cells, we observed a 66% decrease in the mean number of circulating tumor cells in the OPM2-EV-1 model ( P <0.0001; Figure 7C ); while the decrease in circulating tumor cells in the RPMI-8226-luc model did not reach statistical significance ( P =0.09; Figure 7D ).
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Expression of the chemokine receptor CCR1 promotes the dissemination of multiple myeloma plasma cells <i>in vivo</i>
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