Inferred expression regulator activities suggest genes mediating cardiometabolic genetic signals.

Again, the associations between the actual phenotypic measurements and those predicted with the TwinsUK MR random forest models were highly significant for all phenotypes ( Fig 1C, 1F, 1I, 1L and 1O ).

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Strikingly, this BMI signal colocalizes with 15 BMI MR trans -eQTLs ( PP median = 0.67 [range 0.49–0.98]) and 64 BMI MR trans -aQTLs ( PP median = 0.89 [range 0.49–1.00]), though among these nominally significant, colocalized trans -QTL signals, only 8 trans -aQTLs ( ANG , CSNK2A2 , ID2 , PIM1 , PTPRJ , TENM4 , TNFRSF10C and ZFAT ) were significant at FDR < 0.05 ( Fig 4 , and Tables 1 , S11 – S15 and S17 ).

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