Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue.

We further found a borderline significant effect of the ORAI2 editing event on the protein expression of MAPT ( P = 0.068) (Fig. 6f ).

also in 11,409 other papers

But on the level of the cis -effects on the expression of the gene mRNA, the intronic non-coding editing events have less nominally significant effects compared to those events located in the 5′UTR, exons and 3′UTR (Fig. 4a–c , right) where the general patterns of the effect directions were positive rather than negative, indicating that the presence of the non-coding RNA editing events at 5′UTR, exons and 3′UTR were more likely to increase the mRNA expression of the genes.

also in 7,732 other papers