Murine cerebral organoids develop network of functional neurons and hippocampal brain region identity.

Resting membrane potential (RMP) ( Figure 5 B) showed a trend from highly depolarized (lowest RMP:−29 mV) to less depolarized values (highest RMP:−52 mV) from intermediate toward mature organoid cells, although statistical significance was not reached due to the wide range of RMP values exhibited by the organoids at each of these stages (−29.0 [-22.5 to −34.0] mV, n= 5 at 11-13d;−30.0 [-27.0 to −40.0] mV, n = 27 at 19–26 d;−39.0 [-31.0 to −52.0] mV, n = 31 at 33–42 d; ANOVA).

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