Employing an additional cut-off of |0.5| log2FC in defining a significant interaction, we found a positive trend between the number of miRNAs negatively regulating a target and the length of its 3’UTR (Supplementary Fig. 2 B, left panel).
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Coordinated regulation of WNT/β-catenin, c-Met, and integrin signalling pathways by miR-193b controls triple negative breast cancer metastatic traits.
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Unexpectedly, we observed instead a negative trend in correlation for the quantity of miRNAs upregulating protein expression (Supplementary Fig. 2B, right panel).