The role of the sphingosine axis in immune regulation: A dichotomy in the anti-inflammatory effects between sphingosine kinase 1 and sphingosine kinase 2-dependent pathways.

Study limitations While several metrics in the present study did not reach statistical significance, likely due to small sample sizes and the preliminary nature of the study, the noted trends support further studies in additional models for better understanding of the SphK1/SphK2 dichotomy.

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