sGC stimulation lowers elevated blood pressure in a new canine model of resistant hypertension.

5A , the triple combination of enalapril (3.0 mg/kg), furosemide (2.0 mg/kg) and amlodipine (1.0 mg/kg) could decrease the MBP by −18.34 mmHg ± 2.75 mmHg, which was highly significant in comparison to placebo effects ( p = 0.000073) but narrowly missed the therapeutic goal of −20.4 mmHg (averaged MBP increase induced by renal interventions, pre RW versus week 14–58).

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MCP-1, a biomarker of the cellular inflammatory response, showed a trend toward higher levels after renal interventions, but this effect was significant ( p = 0.0464) only 6 weeks post RAO.

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