Association of Serotonergic Pathway Gene Polymorphisms With Behavioral Parameters in Patients With Opioid Dependence.

Cureus · 2021 · PMC8647861 · PMID 34900485

Europe PMC DOI

hedged sentences

0.0610

closest p · 1.2× alpha

0.0610

boldest claim

The sentences

borderline significancep =0.061so close (0.05 < p ≤ 0.1)

There was a borderline significance of the short allele of 5-HTTLPR with the duration of opioid use ( p =0.061) and non-plan impulsivity ( p =0.076), suggesting a role of 5-HTTLPR in the susceptibility of opioid dependence.

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did not reach statistical significanceno p-value reported

Further, the pair-wise comparison revealed the 5-HTTLPR SS genotype to be associated with higher opioid age of dependence as compared to SL genotypes (p=0.012) while 5-HTTLPR also showed an association with the duration of opioid use (p=0.061) and the Barratt non-plan impulsivity score (p=0.076) but did not reach statistical significance (Table 3 ).

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