Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C₁C₂B region.

The double point mutant K706E/R769E within the C 2 B domain Ca 2+ -binding loops displayed stronger defects in the size of the RRP, the EPSC amplitude and the spontaneous release frequency than the K603E/K720E mutant ( Figure 7A and B , Figure 6—figure supplement 2B ), and appeared to have a tendency to lower Pvr than wild type (WT), but the difference did not reach statistical significance ( Figure 7C ).

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