Although CpGi located outside genes were slightly significantly broken (Hscore = 6.41), this significance was much higher when they were located inside the genes (Hscore = 83.30) (Fig. 2 B), with a ratio of Hscores inside/outside genes (RHscore i/o) of 12.99 (Supplemental Table S3 ).
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Medium levels of transcription and replication related chromosomal instability are associated with poor clinical outcome.
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