Human-Specific Transcriptome of Ventral and Dorsal Midbrain Dopamine Neurons.

28 However, we did find 4 increased genes that have been identified as GWAS hits of modest significance for sporadic PD by other smaller studies—3 higher among the dorsal SNpc neurons: MMRN2 (multimerin 2), 48 ANXA1 , 49 and B2M (beta‐2‐microglobulin) 50 ; and 1 higher among the ventral SNpc neurons: AGTR (angiotensin II receptor type 1). 51 Although RNA‐seq is a very powerful technique, some technical artifacts may be present in the data (eg, starting concentrations or cDNA quality), and validation with an independent technique is therefore advisable using different biological replicates from the same population.

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