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Repeated Ethanol Exposure Alters DNA Methylation Status and Dynorphin/Kappa-Opioid Receptor Expression in Nucleus Accumbens of Alcohol-Preferring AA Rats.

Front Genet · 2021 · PMC8652212 · PMID 34899839

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A trend towards a reduction in mRNA levels of Tet genes in the NAc after ethanol treatment was observed, but these changes did not reach statistical significance ( Tet1 , mean ± SEM values: Wistar-water 1.00 ± 0.05; AA-water 1.02 ± 0.05; AA-ethanol 0.91 ± 0.06; Tet2 , mean ± SEM values: Wistar-water 1.00 ± 0.06; AA-water 1.00 ± 0.05; AA-ethanol 0.87 ± 0.05; Tet3 , mean ± SEM values: Wistar-water 1.00 ± 0.07; AA-water 1.00 ± 0.05; AA-ethanol 0.79 ± 0.08, n = 5–7).

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