Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade.

CD8α antibody-mediated depletion showed a trend toward some impact on tumor antigen uptake by CD103 + DCs, which could be an indirect effect of removing CD8α + DCs by the antibody, but transient intratumoral depletion of T cells ( Besançon et al., 2017 ) in the first few days of treatment did not alter long-term survival in response to 1X AIP therapy ( Figure S3I ).

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