Phosphate-mediated coanchoring of RBD immunogens and molecular adjuvants to alum potentiates humoral immunity against SARS-CoV-2.

Examining GC responses 14 days after immunization, antigen-specific GC B cell frequencies showed a slight trend toward increased responses at lower antigen density/higher alum dose, but these differences again were not significant (fig.

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Total binding IgG ELISA titers and hACE2 binding inhibition trended to be higher with pSer 4 -RBDJ versus pSer 8 -RBDJ, but these differences did not reach statistical significance.

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