Autism-Associated DNA Methylation at Birth From Multiple Tissues Is Enriched for Autism Genes in the Early Autism Risk Longitudinal Investigation.

With larger sample sizes, it is likely that true associations will emerge, but are currently among this set of nominally significant CpGs and cannot be distinguished from “noise.” Future work in consortia, such as the Pregnancy And Childhood Epigenetics (PACE) consortium ( Felix et al., 2018 ) may be able to build upon these promising findings in the EARLI study and meta-analyze across studies for CpG-level interrogation.

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