Systematic Review of Cancer Targeting by Nanoparticles Revealed a Global Association between Accumulation in Tumors and Spleen.

Similarly, the correlations between nanoparticle accumulation in tumors and depletion in the spleen were nearly significant for 4T1 breast cancer (R = 0.49) and more significant for B16F10 melanoma (R = 0.98) while, for other tumors, the trend remained but the correlation became not significant ( Figure 2 B).

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