Enhanced Platelet-Rich Plasma (ePRP) Stimulates Wound Healing through Effects on Metabolic Reprogramming in Fibroblasts.

ePRP stifled basal respiration (with a reduction trend, but it did not reach statistical significance) ( Figure 6 B) and the OCR/ECAR ratio (with a very significant reduction) ( Figure 6 C) in fibroblasts, indicating that the ePRP-driven metabolic shift depends on glycolysis rather than mitochondrial oxidative phosphorylation (OXPHOS) for energy generation.

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