Effect of Hyperbaric Oxygenation on Blood Cytokines and Arginine Derivatives; No Evidence for Induction of Inflammation or Endothelial Injury.

The results showed that in patients with necrotising soft tissue infection, an increase in L-NMMA entailed an increase in arginine ( p < 0.0001), homoarginine ( p = 0.027), and ADMA ( p < 0.0001); there was also a positive correlation between arginine and homoarginine ( p = 0.029) and arginine and ADMA ( p = 0.007); the correlation between homoarginine and IL-10 was at the limit of significance ( p = 0.050); the other correlations did not reach statistical significance ( Figure 4 A).

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