Barely Significant
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Epidemiology of Extended-Spectrum Beta-Lactamase and Carbapenemase-Producing Enterobacterales in the Greater Mekong Subregion: A Systematic-Review and Meta-Analysis of Risk Factors Associated With Extended-Spectrum Beta-Lactamase and Carbapenemase Isolation.

Front Microbiol · 2021 · PMC8661499 · PMID 34899618

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showed a trendno p-value reported
coli showed a trend that increased by 13.2% (95%CI: 6.1–20.2) in clinical blood specimens, 8.1% (95%CI: 1.7–14.4) in all clinical specimens and 17.7% (95%CI: 4.9–30.4) increase in carriage specimens.

also in 53,322 other papers

an increasing trendno p-value reported
Surveillance of community-acquired infections has reported a widespread ESBL-mediated resistance and has shown an increasing trend for 10 years ( Kanoksil et al., 2013 ; Fox-Lewis et al., 2018 ; Chang et al., 2020 ).

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.