showed a trendp = 0.056
2 ): T1 > T2 ( p < 0.001); - Time ( F = 33.63; p < 0.001) had a significant effect on the change of HAM-A scores, while diagnosis showed a trend to present a significant effect ( F = 2.36; p = 0.056) ( Fig. 3 ): T0 < T2 and T1 > T2 (both p values <0.001); SKZ patients overall < PD patients ( p = 0.02).